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1

Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors

Mona N. Rahman, Jason Z. Vlahakis, Gheorghe Roman, Dragic Vukomanovic, Walter A. Szarek, Kanji Nakatsu, Zongchao Jia

Journal:

Journal of Inorganic Biochemistry

Année:

2010

Langue:

english

Fichier:

PDF, 582 KB

english, 2010

2

The interaction of imidazole-, imidazolium-, and tetrazolium-containing compounds with DNA

Crandall, Ian E., Zhao, Bohang, Vlahakis, Jason Z., Szarek, Walter A.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 749 KB

english, 2013

3

Synthesis and Evaluation of Azalanstat Analogues as Heme Oxygenase Inhibitors.

Jason Z. Vlahakis, Robert T. Kinobe, Raymond J. Bowers, James F. Brien, Kanji Nakatsu, Walter A. Szarek

Journal:

Année:

2005

Fichier:

PDF, 17 KB

2005

4

Heme Oxygenase Inhibition by 1-Aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl)ethanones and Their Derivatives

Gheorghe Roman, Jason Z. Vlahakis, Dragic Vukomanovic, Kanji Nakatsu, Walter A. Szarek

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 380 KB

english, 2010

5

Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: Effect of halogen substitution in the phenyl ring

Gheorghe Roman, John G. Riley, Jason Z. Vlahakis, Robert T. Kinobe, James F. Brien, Kanji Nakatsu, Walter A. Szarek

Journal:

Bioorganic & Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 247 KB

english, 2007

6

Anti-Plasmodium activity of tetrazolium salts

Xilin Cui, Jason Z. Vlahakis, Ian E. Crandall, Walter A. Szarek

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 434 KB

english, 2008

7

Synthesis and evaluation of imidazole–dioxolane compounds as selective heme oxygenase inhibitors: Effect of substituents at the 4-position of the dioxolane ring

Jason Z. Vlahakis, Maaike Hum, Mona N. Rahman, Zongchao Jia, Kanji Nakatsu, Walter A. Szarek

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 2.18 MB

english, 2009

8

Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors

Jason Z. Vlahakis, Robert T. Kinobe, Raymond J. Bowers, James F. Brien, Kanji Nakatsu, Walter A. Szarek

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 154 KB

english, 2005

9

Anti-Plasmodium activity of imidazolium and triazolium salts

Jason Z. Vlahakis, Carmen Lazar, Ian E. Crandall, Walter A. Szarek

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.82 MB

english, 2010

10

Anti-Plasmodium activity of imidazole–dioxolane compounds

Jason Z. Vlahakis, Robert T. Kinobe, Kanji Nakatsu, Walter A. Szarek, Ian E. Crandall

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 223 KB

english, 2006

11

Selectivity of imidazole–dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms

Robert T Kinobe, Jason Z Vlahakis, Hendrik J Vreman, David K Stevenson, James F Brien, Walter A Szarek, Kanji Nakatsu

Journal:

British Journal of Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 207 KB

english, 2006

12

UDP-Gal: GlcNAc-R β1,4-galactosyltransferase—a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme

Inka Brockhausen, Melinda Benn, Shridhar Bhat, Sandra Marone, John G. Riley, Pedro Montoya-Peleaz, Jason Z. Vlahakis, Hans Paulsen, John S. Schutzbach, Walter A. Szarek

Journal:

Glycoconjugate Journal

Année:

2006

Langue:

english

Fichier:

PDF, 469 KB

english, 2006

13

Thioindigo-containing organosiloxane liquid crystals with electroclinic properties

Vlahakis, Jason Z., Maly, Kenneth E., Lemieux, Robert P.

Journal:

Journal of Materials Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 167 KB

english, 2001

14

Heme Oxygenase Inhibition by α-(1H-Imidazol-1-yl)-ω-phenylalkanes: Effect of Introduction of Heteroatoms in the Alkyl Linker

Dr. Jason Z. Vlahakis, Dr. Carmen Lazar, Dr. Gheorghe Roman, Dr. Dragic Vukomanovic, Prof. Kanji Nakatsu, Prof. Walter A. Szarek

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 236 KB

english, 2012

15

Sulfated cyclodextrins inhibit the entry of Plasmodium into red blood cells: Implications for malarial therapy

Ian E. Crandall, Walter A. Szarek, Jason Z. Vlahakis, Yiming Xu, Rahul Vohra, Jie Sui, Robert Kisilevsky

Journal:

Biochemical Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 765 KB

english, 2007

16

The anti-malarial activity of bivalent imidazolium salts

Jason Z. Vlahakis, Simona Mitu, Gheorghe Roman, E. Patricia Rodriguez, Ian E. Crandall, Walter A. Szarek

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2011

17

Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition

Jason Z. Vlahakis, Mona N. Rahman, Gheorghe Roman, Zongchao Jia, Kanji Nakatsu, Walter A. Szarek

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2011

Langue:

english

Fichier:

PDF, 749 KB

english, 2011

18

Selective inhibition of glycosyltransferases by bivalent imidazolium salts

Gao, Yin, Vlahakis, Jason Z., Szarek, Walter A., Brockhausen, Inka

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 278 KB

english, 2013

19

X-ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 1-(Adamantan-1-yl)-2-(1 H -imidazol-1-yl)ethanone: A Common Binding Mode for Imidazole-Based Heme Oxygenase-1 Inhibitors #

Rahman, Mona N., Vlahakis, Jason Z., Szarek, Walter A., Nakatsu, Kanji, Jia, Zongchao

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.56 MB

english, 2008

20

Photoswitching of ferroelectric liquid crystals using unsymmetrical chiral thioindigo dopants: structural effects on polarization photomodulation

Vlahakis, Jason Z., Lemieux, Robert P.

Journal:

Journal of Materials Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 312 KB

english, 2004

21

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position

Vlahakis, Jason Z., Vukomanovic, Dragic, Nakatsu, Kanji, Szarek, Walter A.

Journal:

Bioorganic & Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 385 KB

english, 2013

22

Acceptor specificities and selective inhibition of recombinant human Gal- and GlcNAc-transferases that synthesize core structures 1, 2, 3 and 4 of O-glycans

Gao, Yin, Aryal, Rajindra P., Ju, Tongzhong, Cummings, Richard D., Gahlay, Gagandeep, Jarvis, Donald L., Matta, Khushi L., Vlahakis, Jason Z., Szarek, Walter A., Brockhausen, Inka

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

2013

Langue:

english

Fichier:

PDF, 412 KB

english, 2013

23

X-ray Crystal Structure of Human Heme Oxygenase-1 with (2 R ,4 S )-2-[2-(4-Chlorophenyl)ethyl]-2-[(1 H -imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: A Novel, Inducible Binding Mode

Rahman, Mona N., Vlahakis, Jason Z., Vukomanovic, Dragic, Szarek, Walter A., Nakatsu, Kanji, Jia, Zongchao

Journal:

Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 3.24 MB

english, 2009

24

Imidazole−Dioxolane Compounds as Isozyme-Selective Heme Oxygenase Inhibitors

Vlahakis, Jason Z., Kinobe, Robert T., Bowers, Raymond J., Brien, James F., Nakatsu, Kanji, Szarek, Walter A.

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 79 KB

english, 2006

25

Photoinduced Polarization Inversion in a Ferroelectric Liquid Crystal Using an Ambidextrous Chiral Thioindigo Dopant

Vlahakis, Jason Z., Wand, Michael D., Lemieux, Robert P.

Journal:

Journal of the American Chemical Society

Année:

2003

Langue:

english

Fichier:

PDF, 50 KB

english, 2003

26

Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease

Gupta, Ajay, Lacoste, Baptiste, Pistel, Paul J., Ingram, Donald K., Hamel, Edith, Alaoui-Jamali, Moulay A., Szarek, Walter A., Vlahakis, Jason Z., Jie, Su, Song, Wei, Schipper, Hyman M.

Journal:

Journal of Neurochemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2014

27

Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors

Vukomanovic, Dragic, McLaughlin, Brian, Rahman, Mona N., Vlahakis, Jason Z., Roman, Gheorghe, Dercho, Ryan A., Kinobe, Robert T., Hum, Maaike, Brien, James F., Jia, Zongchao, Szarek, Walter A., Nakats

Journal:

Canadian Journal of Physiology and Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 147 KB

english, 2010

28

Biosynthesis of the Common Polysaccharide Antigen of Pseudomonas aeruginosa PAO1: Characterization and Role of GDP-d-Rhamnose:GlcNAc/GalNAc-Diphosphate-Lipid α1,3-d-Rhamnosyltransferase WbpZ

Wang, Shuo, Hao, Youai, Lam, Joseph S., Vlahakis, Jason Z., Szarek, Walter A., Vinnikova, Anna, Veselovsky, Vladimir V., Brockhausen, Inka, Metcalf, W. W.

Journal:

Journal of Bacteriology

Année:

2015

Langue:

english

Fichier:

PDF, 812 KB

english, 2015

29

Heme oxygenase activity in fetal and adult sheep is not altered by acclimatization to high altitude hypoxia

Kinobe, Robert T., Vlahakis, Jason Z., Soong, Jonathan M., Szarek, Walter A., Brien, James F., Longo, Lawrence D., Nakatsu, Kanji

Journal:

Canadian Journal of Physiology and Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 258 KB

english, 2006

30

Differential inhibition of rat and mouse microsome heme oxygenase by derivatives of imidazole and benzimidazole

Hum, Maaike, McLaughlin, Brian E, Kong, Xianqi, Vlahakis, Jason Z, Vukomanovic, Dragic, Szarek, Walter A, Nakatsu, Kanji

Journal:

Canadian Journal of Physiology and Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2017

31

Antitumor Effect of a Liposome-Encapsulated β1,4-Galactosyltransferase Inhibitor

Cai, Guangsheng, Wang, Kun, Qu, Na, Qiu, Pengyou, Vlahakis, Jason Z., Szarek, Walter A., Lee, Robert J., Gao, Yin

Journal:

International Journal of Pharmaceutics

Année:

2018

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2018

32

Inhibition of bacterial growth and galactosyltransferase activity of WbwC by Î±, Ï-bis(3-alkyl-1H-imidazolium)alkane salts: Effect of varying carbon content

Kocev, Alexander, Melamed, Jacob, Wang, Shuo, Kong, Xianqi, Vlahakis, Jason Z., Xu, Yaozu, Szarek, Walter A., Brockhausen, Inka

Journal:

Bioorganic & Medicinal Chemistry

Année:

2020

Fichier:

PDF, 675 KB

2020